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Published online on March 15, 2005, 10.1073/pnas.0409891102

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Evolution
Resolution of a deep animal divergence by the pattern of intron conservation

( coelomata | ecdyosozoa | intron evolution | phylogenetics )

Scott William Roy * and Walter Gilbert

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138

Contributed by Walter Gilbert, January 18, 2005

The relationship between three biologically important groups, arthropods, nematodes, and deuterostomes, remains unresolved. It is unknown whether arthropods are more closely related to nematodes (consistent with the "ecdysozoa" hypothesis) or to deuterostomes (consistent with "coelomata"). We present a method in which we use the pattern of spliceosomal intron conservation to develop a series of inequalities that characterize each possible relationship. We find that only the ecdysozoa grouping satisfies these predictions, with P < 10-6. Simulations show that our method, unlike some previous methods, is largely insensitive to rate variation between branches.

*To whom correspondence should be addressed.

Scott William Roy, E-mail: scottroy{at}fas.harvard.edu

www.pnas.org/cgi/doi/10.1073/pnas.0409891102
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