( lateral genetic transfer |
microbial genomes |
molecular phylogeny )
Institute for Molecular Bioscience and Australian Research Council Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia
Edited by Carl R. Woese, University of Illinois at Urbana-Champaign, Urbana, IL, and approved August 17, 2005 (received for review May 16, 2005) The extent to which lateral genetic transfer has shaped microbial genomes has major implications for the emergence of community structures. We have performed a rigorous phylogenetic analysis of >220,000 proteins from genomes of 144 prokaryotes to determine the contribution of gene sharing to current prokaryotic diversity, and to identify "highways" of sharing between lineages. The inferred relationships suggest a pattern of inheritance that is largely vertical, but with notable exceptions among closely related taxa, and among distantly related organisms that live in similar environments.
Evolution
Highways of gene sharing in prokaryotes
Author contributions: R.G.B. and M.A.R. designed research; R.G.B. and T.J.H. performed research; R.G.B. and T.J.H. contributed new reagents/analytic tools; R.G.B., T.J.H., and M.A.R. analyzed data; and R.G.B. and M.A.R. wrote the paper.
*To whom correspondence should be addressed.
Mark A. Ragan, E-mail: m.ragan{at}imb.uq.edu.au
www.pnas.org/cgi/doi/10.1073/pnas.0504068102
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