Make Illumina part of your DNA Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search

Published online on September 18, 2007, 10.1073/pnas.0704380104

This Article
Right arrow Full Text (PDF)
Right arrow Supporting Figure
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fransson, P.
Right arrow Articles by Åden, U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fransson, P.
Right arrow Articles by Åden, U.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

Neuroscience
Resting-state networks in the infant brain

( development | functional MRI | spontaneous activity )

Peter Fransson {dagger}{ddagger}, Beatrice Skiöld {sect}, Sandra Horsch {sect}¶, Anders Nordell {dagger}, Mats Blennow ||, Hugo Lagercrantz {sect}, and Ulrika Åden {sect}

{dagger}Magnetic Resonance Research Center, Department of Clinical Neuroscience, Stockholm Brain Institute, Karolinska Institute, SE-171 77 Stockholm, Sweden; {sect}Neonatal Research Unit, Astrid Lindgren Children's Hospital, Karolinska Institute, SE-171 76 Stockholm, Sweden; Department of Neonatology, Erasmus MC-Sophia Children's Hospital, 3000 CB, Rotterdam, The Netherlands; and ||Department of Clinical Science, Intervention, and Technology, Karolinska Institute, S-141 57 Huddinge, Sweden

Edited by Jean-Pierre Changeux, Institut Pasteur, Paris, France, and approved August 15, 2007 (received for review May 11, 2007)

In the absence of any overt task performance, it has been shown that spontaneous, intrinsic brain activity is expressed as systemwide, resting-state networks in the adult brain. However, the route to adult patterns of resting-state activity through neuronal development in the human brain is currently unknown. Therefore, we used functional MRI to map patterns of resting-state activity in infants during sleep. We found five unique resting-states networks in the infant brain that encompassed the primary visual cortex, bilateral sensorimotor areas, bilateral auditory cortex, a network including the precuneus area, lateral parietal cortex, and the cerebellum as well as an anterior network that incorporated the medial and dorsolateral prefrontal cortex. These results suggest that resting-state networks driven by spontaneous signal fluctuations are present already in the infant brain. The potential link between the emergence of behavior and patterns of resting-state activity in the infant brain is discussed.

Author contributions: P.F., M.B., H.L., and U.Å. designed research; P.F., B.S., S.H., and A.N. performed research; P.F. contributed new reagents/analytic tools; P.F. analyzed data; and P.F., H.L., and U.Å. wrote the paper.

The authors declare no conflict of interest.

{ddagger}To whom correspondence should be addressed at: MR Research Center, N8, Department of Clinical Neuroscience, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

Peter Fransson, E-mail: Peter.Fransson{at}ki.se

www.pnas.org/cgi/doi/10.1073/pnas.0704380104
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Fair, A. L. Cohen, N. U. F. Dosenbach, J. A. Church, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar
The maturing architecture of the brain's default network
PNAS, March 11, 2008; 105(10): 4028 - 4032.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
R. L. BUCKNER, J. R. ANDREWS-HANNA, and D. L. SCHACTER
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 1 - 38.
[Abstract] [Full Text] [PDF]