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Medical Sciences
Molecular imaging with endogenous substances
*Amersham Health Research and Development AB,
Medeon, SE-205 12 Malmö, Sweden; and
Department of Experimental Research,
Malmö University Hospital, SE-205 02 Malmö, Sweden
Communicated by Albert W. Overhauser, Purdue University, West Lafayette, IN, June 20, 2003 (received for review April 16, 2003)
Dynamic nuclear polarization has enabled hyperpolarization of nuclei such
as 13C and 15N in endogenous substances. The resulting
high nuclear polarization makes it possible to perform subsecond
13C MRI. By using the dynamic nuclear polarization
hyperpolarization technique, 10% polarization was obtained in an aqueous
solution of 100 mM 13C-labeled urea, ready for injection. The
in vivo T1 relaxation time of 13C in the urea
solution was determined to 20 ± 2 s. Due to the long relaxation time,
it is possible to use the hyperpolarized substance for medical imaging. A
series of high-resolution (
1-mm) magnetic resonance images were acquired,
each with a scan time of 240 ms, 0-5 s after an i.v. injection of the
hyperpolarized aqueous [13C]urea solution in a rat. The results
show that it is possible to perform 13C angiography with a
signal-to-noise ratio of 275 in 0.25 s. Perfusion studies with
endogenous substances may allow higher spatial and/or temporal resolution than
is possible with current proton imaging techniques.
To whom correspondence should be addressed. E-mail:
klaes.golman{at}amersham.com.
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