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From The Cover
Neuroscience
An emotion-induced retrograde amnesia in humans is amygdala- and -adrenergic-dependent

B. A. Strange ^*  , R. Hurlemann , and R. J. Dolan ^*

^*Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom; Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, United Kingdom; and Department of Neurology II, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany

Communicated by Endel Tulving, Rotman Research Institute of Baycrest Centre, North York, ON, Canada, August 10, 2003 (received for review May 20, 2003)

The influence of emotion on human memory is associated with two contradictory effects in the form of either emotion-induced enhancements or decrements in memory. In a series of experiments involving single word presentation, we show that enhanced memory for emotional words is strongly coupled to decrements in memory for items preceding the emotional stimulus, an effect that is more pronounced in women. These memory effects would appear to depend on a common neurobiological substrate, in that enhancements and decrements are reversed by propranolol, a -adrenergic antagonist, and abolished by selective bilateral amygdala damage. Thus, our findings suggest that amygdala-dependent -adrenergic modulation of episodic encoding has costs as well as benefits.

See Commentary on page 13123.

To whom correspondence should be addressed. E-mail: bstrange{at}fil.ion.ucl.ac.uk.

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Related Commentary in PNAS:

Similar neural mechanisms for emotion-induced memory impairment and enhancement

Larry Cahill
PNAS 2003 100: 13123-13124. [Extract] [Full Text]  

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