OriGene Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search

Published online on August 2, 2004, 10.1073/pnas.0402374101
PNAS | August 10, 2004 | vol. 101 | no. 32 | 11725-11730
OPEN ACCESS ARTICLE


This Article
Free via Open Access: OA
Right arrow OA Full Text
Right arrow Full Text (PDF)
Right arrow Suppporting Information
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neff, M. W.
Right arrow Articles by Pedersen, N. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neff, M. W.
Right arrow Articles by Pedersen, N. C.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

From the Cover
GENETICS
Breed distribution and history of canine mdr1-1{Delta}, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage

Mark W. Neff *, {dagger}, Kathryn R. Robertson *, Aaron K. Wong *, Noa Safra *, Karl W. Broman {ddagger}, Montgomery Slatkin §, Katrina L. Mealey ¶, and Niels C. Pedersen *

*Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616; {ddagger}Department of Biostatistics, Johns Hopkins University, Baltimore, MD 21205; §Department of Integrative Biology, University of California, Berkeley, CA 94720; and Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164

Edited by Arno G. Motulsky, University of Washington, Seattle, WA, and approved June 22, 2004 (received for review April 3, 2004)

A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele, mdr1-1{Delta}, segregated in seven additional breeds, including two sighthounds that were not expected to share collie ancestry. A mutant haplotype that was conserved among affected breeds indicated that the allele was identical by descent. Based on breed histories and the extent of linkage disequilibrium, we conclude that all dogs carrying mdr1-1{Delta} are descendants of a dog that lived in Great Britain before the genetic isolation of breeds by registry (ca. 1873). The breed distribution and frequency of mdr1-1{Delta} have applications in veterinary medicine and selective breeding, whereas the allele's history recounts the emergence of formally recognized breeds from an admixed population of working sheepdogs.

allele age | Canis familiaris | drug sensitivity | identity by descent | P-glycoprotein

This paper was submitted directly (Track II) to the PNAS office.

Freely available online through the PNAS open access option.

Abbreviation: LD, linkage disequilibrium.

{dagger} To whom correspondence should be addressed. E-mail: mwneff{at}ucdavis.edu.

© 2004 by The National Academy of Sciences of the USA


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Drug Metab. Dispos.Home page
Y. Kitamura, H. Koto, S. Matsuura, T. Kawabata, H. Tsuchiya, H. Kusuhara, H. Tsujimoto, and Y. Sugiyama
Modest Effect of Impaired P-glycoprotein on the Plasma Concentrations of Fexofenadine, Quinidine, and Loperamide following Oral Administration in Collies
Drug Metab. Dispos., May 1, 2008; 36(5): 807 - 810.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
H. G. Parker, A. V. Kukekova, D. T. Akey, O. Goldstein, E. F. Kirkness, K. C. Baysac, D. S. Mosher, G. D. Aguirre, G. M. Acland, and E. A. Ostrander
Breed relationships facilitate fine-mapping studies: A 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds
Genome Res., November 1, 2007; 17(11): 1562 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 Journal of the American Animal Hospital AssociationHome page
D. H. Thamm and D. M. Vail
Aftershocks of Cancer Chemotherapy: Managing Adverse Effects
J. Am. Anim. Hosp. Assoc., January 1, 2007; 43(1): 1 - 7.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
A. E. Pires, L. Ouragh, M. Kalboussi, J. Matos, F. Petrucci-Fonseca, and M. W. Bruford
Mitochondrial DNA Sequence Variation in Portuguese Native Dog Breeds: Diversity and Phylogenetic Affinities
J. Hered., July 1, 2006; 97(4): 318 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. Clark, J. M. Wahl, C. A. Rees, and K. E. Murphy
From The Cover: Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog
PNAS, January 31, 2006; 103(5): 1376 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
E. A. Ostrander and R. K. Wayne
The canine genome
Genome Res., December 1, 2005; 15(12): 1706 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
I. K. Puja, D. N. Irion, A. L. Schaffer, and N. C. Pedersen
The Kintamani Dog: Genetic Profile of an Emerging Breed from Bali, Indonesia
J. Hered., November 1, 2005; 96(7): 854 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page

Vet. Pathol., November 1, 2004; 41(6): 712 - 712.
[Full Text] [PDF]