Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle

  1. David J. Richard,
  2. Bruno Schiavi, and
  3. Madeleine M. Joullié*
  1. Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323
  1. Edited by Kyriacos C. Nicolaou, The Scripps Research Institute, La Jolla, CA (received for review April 9, 2004)

Abstract

The syntheses of isoroquefortine C and a related heterocycle were achieved by implementation of both intra- and intermolecular vinyl amidation reactions. These accomplishments represent a significant advance in the use of these strategies in the generation of complex molecules.

Footnotes

  • * To whom correspondence should be addressed. E-mail: mjoullie{at}sas.upenn.edu.

  • This paper was submitted directly (Track II) to the PNAS office.

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