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EVOLUTION
Highways of gene sharing in prokaryotes

Robert G. Beiko, Timothy J. Harlow, and Mark A. Ragan ^*

Institute for Molecular Bioscience and Australian Research Council Centre in Bioinformatics, The University of Queensland, Brisbane 4072, Australia

Edited by Carl R. Woese, University of Illinois at Urbana-Champaign, Urbana, IL, and approved August 17, 2005 (received for review May 16, 2005)

The extent to which lateral genetic transfer has shaped microbial genomes has major implications for the emergence of community structures. We have performed a rigorous phylogenetic analysis of >220,000 proteins from genomes of 144 prokaryotes to determine the contribution of gene sharing to current prokaryotic diversity, and to identify "highways" of sharing between lineages. The inferred relationships suggest a pattern of inheritance that is largely vertical, but with notable exceptions among closely related taxa, and among distantly related organisms that live in similar environments.

lateral genetic transfer | microbial genomes | molecular phylogeny

This paper was submitted directly (Track II) to the PNAS office.

Abbreviations: rDNA, rRNA gene; LGT, lateral genetic transfer; MRC, maximally representative cluster; PP, posterior probability.

^* To whom correspondence should be addressed. E-mail: m.ragan{at}imb.uq.edu.au.

© 2005 by The National Academy of Sciences of the USA

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