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NEUROSCIENCE
Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
*Functional Neuroimaging Laboratory, Department of Psychiatry, and Iris Cantor Women's Health Center, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021; and Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021
Edited by Marcus E. Raichle, Washington University School of Medicine, St. Louis, MO and approved September 15, 2005 (received for review April 5, 2005)
The orbitofrontal cortex (OFC) has been implicated in the representation of emotional stimuli, assignment of emotional valence/salience to stimuli, stimulus-reinforcement association learning, motivation, and socio-emotional control. Using functional magnetic resonance imaging in female subjects without premenstrual mood symptoms, we found that OFC activity to emotional linguistic stimuli varies depending on the menstrual cycle phase. Specifically, anterior-medial OFC activity for negative vs. neutral stimuli was increased premenstrually and decreased postmenstrually. The inverse pattern was seen in the lateral OFC. These findings suggest that specific subregional OFC activity to emotional stimuli is modulated across the menstrual cycle. The data also demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation.
functional MRI | brain | mood | emotion | women
Conflict of interest statement: No conflicts declared.
This paper was submitted directly (Track II) to the PNAS office.
Abbreviations: OFC, orbitofrontal cortex; BOLD, blood oxygen level-dependent; fMRI, functional MRI; PMDD, premenstrual dysphoric disorder; DSRP, Daily Record of Severity of Problems.
¶ To whom correspondence should be addressed. E-mail: estern{at}med.cornell.edu.
© 2005 by The National Academy of Sciences of the USA
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