An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni –hookworm coinfection

doi:10.1073/pnas.0601559103

An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni–hookworm coinfection

*Department of Public Health and Epidemiology, Swiss Tropical Institute, P.O. Box, CH-4002 Basel, Switzerland;
^†Molecular Parasitology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia;
^‡Office of Population Research, Princeton University, Princeton, NJ 08544;
^¶Centre Suisse de Recherches Scientifiques, 01 BP 1303, Abidjan 01, Côte d’Ivoire; and
^‖UFR Biosciences, Université d’Abidjan–Cocody, 22 BP 770, Abidjan 22, Côte d’Ivoire

Contributed by Burton H. Singer, March 6, 2006

Abstract

Multiple-species parasitic infections are pervasive in the developing world, yet resources for their control are scarce. We present an integrated approach for risk profiling and spatial prediction of coinfection with Schistosoma mansoni and hookworm for western Côte d’Ivoire. Our approach combines demographic, environmental, and socioeconomic data; incorporates them into a geographic information system; and employs spatial statistics. Demographic and socioeconomic data were obtained from education registries and from a questionnaire administered to schoolchildren. Environmental data were derived from remotely sensed satellite images and digitized ground maps. Parasitologic data, obtained from fecal examination by using two different diagnostic approaches, served as the outcome measure. Bayesian variogram models were used to assess risk factors and spatial variation of S. mansoni–hookworm coinfection in relation to demographic, environmental, and socioeconomic variables. Coinfections were found in 680 of 3,578 schoolchildren (19.0%) with complete data records. The prevalence of monoinfections with either hookworm or S. mansoni was 24.3% and 24.1%, respectively. Multinomial Bayesian spatial models showed that age, sex, socioeconomic status, and elevation were good predictors for the spatial distribution of S. mansoni–hookworm coinfection. We conclude that our integrated approach, employing a diversity of data sources, geographic information system and remote sensing technologies, and Bayesian spatial statistics, is a powerful tool for risk profiling and spatial prediction of S. mansoni–hookworm coinfection. More generally, this approach facilitates risk mapping and prediction of other parasite combinations and multiparasitism, and hence can guide integrated disease control programs in resource-constrained settings.

Footnotes

^§To whom correspondence may be addressed. E-mail: singer{at}princeton.edu or juerg.utzinger{at}unibas.ch
Author contributions: G.R. and J.U. designed research; G.R. and E.K.N. performed research; G.R. and P.V. analyzed data; and G.R., P.V., B.H.S., M.T., and J.U. wrote the paper.
Conflict of interest statement: No conflicts declared.
Abbreviations:

Abbreviations:

BCI,

Bayesian credible interval;

OR,

odds ratio;

RRR,

risk ratio ratio;

CI,

confidence interval;

SAF,

sodium–acetic acid–formalin