OriGene Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search

Published online on October 18, 2006, 10.1073/pnas.0607822103
PNAS | October 31, 2006 | vol. 103 | no. 44 | 16568-16573


This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maher, P.
Right arrow Articles by Abe, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maher, P.
Right arrow Articles by Abe, K.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Memory
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

BIOLOGICAL SCIENCES / NEUROSCIENCE
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory

Pamela Maher*,{dagger}, Tatsuhiro Akaishi{ddagger}, and Kazuho Abe{ddagger}

*The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037; and {ddagger}Laboratory of Pharmacology, Research Institute of Pharmaceutical Sciences, Musashino University, Nishitokyo-shi, Tokyo 202-8585, Japan

Communicated by Roger Guillemin, The Salk Institute for Biological Studies, La Jolla, CA, September 6, 2006 (received for review July 19, 2006)

Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.

cAMP response element binding protein (CREB) | phosphorylation | learning | polyphenol | natural product

Author contributions: P.M. and K.A. designed research; P.M. and T.A. performed research; P.M., T.A., and K.A. analyzed data; and P.M. wrote the paper.

The authors declare no conflict of interest.

{dagger}To whom correspondence should be addressed. E-mail: pmaher{at}salk.edu

© 2006 by The National Academy of Sciences of the USA


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 J. Neurosci.Home page
H. van Praag, M. J. Lucero, G. W. Yeo, K. Stecker, N. Heivand, C. Zhao, E. Yip, M. Afanador, H. Schroeter, J. Hammerstone, et al.
Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
J. Neurosci., May 30, 2007; 27(22): 5869 - 5878.
[Abstract] [Full Text] [PDF]