Yeast two-hybrid screening service Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search

Published online on June 18, 2007, 10.1073/pnas.0704320104
PNAS | June 26, 2007 | vol. 104 | no. 26 | 11073-11078


This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supporting Information
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dosenbach, N. U. F.
Right arrow Articles by Petersen, S. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dosenbach, N. U. F.
Right arrow Articles by Petersen, S. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

BIOLOGICAL SCIENCES / NEUROSCIENCE
Distinct brain networks for adaptive and stable task control in humans

Nico U. F. Dosenbach*,{dagger}, Damien A. Fair{ddagger}, Francis M. Miezin*,{ddagger}, Alexander L. Cohen*, Kristin K. Wenger{ddagger}, Ronny A. T. Dosenbach*,{ddagger}, Michael D. Fox*, Abraham Z. Snyder*,{ddagger}, Justin L. Vincent*, Marcus E. Raichle*,{dagger},{ddagger},§, Bradley L. Schlaggar*,{ddagger},§,¶, and Steven E. Petersen*,{dagger},{ddagger},¶,||

Departments of *Radiology, {ddagger}Neurology, §Neurobiology and Anatomy, Pediatrics, and ||Psychology, Washington University, St. Louis, MO 63110

Contributed by Marcus E. Raichle, May 8, 2007 (received for review March 28, 2007)

Control regions in the brain are thought to provide signals that configure the brain's moment-to-moment information processing. Previously, we identified regions that carried signals related to task-control initiation, maintenance, and adjustment. Here we characterize the interactions of these regions by applying graph theory to resting state functional connectivity MRI data. In contrast to previous, more unitary models of control, this approach suggests the presence of two distinct task-control networks. A frontoparietal network included the dorsolateral prefrontal cortex and intraparietal sulcus. This network emphasized start-cue and error-related activity and may initiate and adapt control on a trial-by-trial basis. The second network included dorsal anterior cingulate/medial superior frontal cortex, anterior insula/frontal operculum, and anterior prefrontal cortex. Among other signals, these regions showed activity sustained across the entire task epoch, suggesting that this network may control goal-directed behavior through the stable maintenance of task sets. These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms.

attention | connectivity | executive control | functional MRI | task set

Author contributions: N.U.F.D. and S.E.P. designed research; N.U.F.D. performed research; M.D.F., A.Z.S., J.L.V., and M.E.R. contributed new reagents/analytic tools; N.U.F.D., D.A.F., F.M.M., A.L.C., K.K.W., R.A.T.D., and B.L.S. analyzed data; and N.U.F.D., D.A.F., B.L.S., and S.E.P. wrote the paper.

The authors declare no conflict of interest.

This article contains supporting information online at www.pnas.org/cgi/content/full/0704320104/DC1.

{dagger}To whom correspondence may be addressed. E-mail: ndosenbach{at}wustl.edu, marc{at}npg.wustl.edu, or sep{at}npg.wustl.edu

© 2007 by The National Academy of Sciences of the USA


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Neurorehabil Neural RepairHome page
J. Ghajar and R. B. Ivry
The Predictive Brain State: Timing Deficiency in Traumatic Brain Injury?
Neurorehabil Neural Repair, June 1, 2008; 22(3): 217 - 227.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Eichele, S. Debener, V. D. Calhoun, K. Specht, A. K. Engel, K. Hugdahl, D. Y. von Cramon, and M. Ullsperger
Prediction of human errors by maladaptive changes in event-related brain networks
PNAS, April 22, 2008; 105(16): 6173 - 6178.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
A. Di Martino, A. Scheres, D.S. Margulies, A.M.C. Kelly, L.Q. Uddin, Z. Shehzad, B. Biswal, J.R. Walters, F.X. Castellanos, and M.P. Milham
Functional Connectivity of Human Striatum: A Resting State fMRI Study
Cereb Cortex, April 9, 2008; (2008) bhn041v1.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Fair, A. L. Cohen, N. U. F. Dosenbach, J. A. Church, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar
The maturing architecture of the brain's default network
PNAS, March 11, 2008; 105(10): 4028 - 4032.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
E. Takahashi, K. Ohki, and D.-S. Kim
Dissociated Pathways for Successful Memory Retrieval from the Human Parietal Cortex: Anatomical and Functional Connectivity Analyses
Cereb Cortex, January 7, 2008; (2008) bhm204v2.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. J. Ploran, S. M. Nelson, K. Velanova, D. I. Donaldson, S. E. Petersen, and M. E. Wheeler
Evidence Accumulation and the Moment of Recognition: Dissociating Perceptual Recognition Processes Using fMRI
J. Neurosci., October 31, 2007; 27(44): 11912 - 11924.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Fair, N. U. F. Dosenbach, J. A. Church, A. L. Cohen, S. Brahmbhatt, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar
Development of distinct control networks through segregation and integration
PNAS, August 14, 2007; 104(33): 13507 - 13512.
[Abstract] [Full Text] [PDF]