Effect of carbonates/phosphates as nucleophilic catalysts in dimethylformamide for efficient cyanosilylation of aldehydes and ketones
- G. K. Surya Prakash,
- Habiba Vaghoo,
- Chiradeep Panja,
- Vijayalakshmi Surampudi,
- Roman Kultyshev,
- Thomas Mathew, and
- George A. Olah†
- Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661
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Contributed by George A. Olah, December 19, 2006 (received for review November 27, 2006)
Abstract
Cyanosilylation of aldehydes and aliphatic ketones can be carried out in dimethylformamide even without the use of any catalyst. In the presence of nucleophilic catalysts such as carbonate and phosphate salts, the reaction rate is significantly enhanced.
Footnotes
- †To whom correspondence may be addressed. E-mail: olah{at}usc.edu
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Author contributions: G.K.S.P., H.V., C.P., V.S., R.K., T.M., and G.A.O. designed research.
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The authors declare no conflict of interest.
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This article contains supporting information online at www.pnas.org/cgi/content/full/0611309104/DC1.
- Abbreviations:
- DMF,
- dimethylformamide;
- TMSCN,
- trimethylsilyl cyanide.
- © 2007 by The National Academy of Sciences of the USA
