Contributed by R. Webster, June 13, 2000
In 1997, 18 cases of influenza in Hong Kong (bird flu) caused by a
novel H5N1 (chicken) virus resulted in the deaths of six individuals
and once again raised the specter of a potentially devastating
influenza pandemic. Slaughter of the poultry in the live bird markets
removed the source of infection and no further human cases of H5N1
infection have occurred. In March 1999, however, a new pandemic threat
appeared when influenza A H9N2 viruses infected two children in Hong
Kong. These two virus isolates are similar to an H9N2 virus isolated
from a quail in Hong Kong in late 1997. Although differing in their
surface hemagglutinin and neuraminidase components, a notable feature
of these H9N2 viruses is that the six genes encoding the internal
components of the virus are similar to those of the 1997 H5N1 human and
avian isolates. This common feature emphasizes the apparent propensity
of avian viruses with this genetic complement to infect humans and
highlights the potential for the emergence of a novel human pathogen.
Microbiology
Avian-to-human transmission of H9N2 subtype influenza A viruses:
Relationship between H9N2 and H5N1 human isolates
,
,,,,,
,,, and
Division of Virology, National Institute for Medical
Research, Mill Hill, London, NW7 1AA, United Kingdom;
§ Government Virus Unit, Queen Mary Hospital, Hong Kong
SAR, People's Republic of China; Influenza Branch,
Division of Viral and Rickettsial Diseases, Centers for Disease Control
and Prevention, Atlanta, GA 30333; ¶ Department of Virology
and Molecular Biology, St. Jude Children's Research Hospital, Memphis,
TN 38105; and Microbiology Department, University of
Hong Kong, University Pathology Building, Queen Mary Hospital, Hong
Kong SAR, People's Republic of China
*
To whom reprint requests should be addressed. E-mail:
lyipu{at}nimr.mrc.ac.uk.
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