A MUTANT OF YEAST APPARENTLY DEFECTIVE IN THE INITIATION OF PROTEIN SYNTHESIS*

  1. Leland H. Hartwell† and
  2. Calvin S. McLaughlin
  1. DEPARTMENT OF MOLECULAR AND CELL BIOLOGY, UNIVERSITY OF CALIFORNIA (IRVINE)

Abstract

A temperature-sensitive mutant of yeast, ts-187, which is apparently unable to initiate the synthesis of new polypeptide chains after a short incubation at the restrictive temperature, is described. The existence of this mutant demonstrates that in eucaryotic cells, as in procaryotic cells, there are processes unique to the initiation of polypeptide chains.

Footnotes

  • ↵ † Department of Genetics, University of Washington, Seattle, Washington 98105.

  • ↵ * This work was supported by USPH grants GM 13304 and CA 10628 and National Sciences Foundation grants GB4828 and GB8028.

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  1. PNAS 1969-02 vol. 62 no. 2 468-474
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