DIFFERENCES IN THE TRANSFER RNA'S OF NORMAL LIVER AND NOVIKOFF HEPATOMA*

  1. B. S. Baliga,
  2. E. Borek,
  3. I. B. Weinstein, and
  4. P. R. Srinivasan
  1. DEPARTMENT OF BIOCHEMISTRY, COLLEGE OF PHYSICIANS AND SURGEONS, COLUMBIA UNIVERSITY
  2. DEPARTMENT OF MEDICINE, COLLEGE OF PHYSICIANS AND SURGEONS, COLUMBIA UNIVERSITY

Abstract

—A comparison of the elution profiles of 18 aminoacyl-tRNA's from Novikoff hepatoma with those from normal liver on a methylated albuminkieselguhr column revealed the occurrence of new species of tRNA for histidine, tyrosine, and asparagine in the hepatoma. In addition, the hepatoma tRNA's for arginine, isoleucine, lysine, methionine, serine, alanine, and tryptophan eluted at a higher salt concentration than the corresponding tRNA's of normal liver. The remaining eight amino acids did not show any significant differences in the elution profiles.

Footnotes

  • ↵ * Supported by grants from NIH (GM 13826) and NSF (GB 7971). Dr. I. B. Weinstein is a career scientist of the Health Research Council of the City of New York (I-190).

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  1. PNAS 1969-03 vol. 62 no. 3 899-905
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