BIRADICAL SPIN LABELING FOR NERVE MEMBRANES*

  1. M. Calvin,
  2. H. H. Wang,
  3. G. Entine,
  4. D. Gill,
  5. P. Ferruti§,
  6. M. A. Harpold**, and
  7. M. P. Klein
  1. LABORATORY OF CHEMICAL BIODYNAMICS, LAWRENCE RADIATION LABORATORY, UNIVERSITY OF CALIFORNIA, BERKELEY
  2. DEPARTMENT OF CHEMISTRY, UNIVERSITY OF CALIFORNIA, BERKELEY

Abstract

We have explored the behavior of pair interaction in a suitable biradical when it is bound by van der Waals' forces in a nerve membrane. We have concomitantly examined a set of model solvents to represent this situation. It appears that the biradical suffers a restriction of internal motion with a minimal restraint on its external motion in the nerve medium. The biradical is so situated as not to respond to the passage of the action potential.

Footnotes

  • Physics Department, University of California, Berkeley.

  • On leave from the Hebrew University, Jerusalem, Israel.

  • § Permanent address: Instituto di Chimica Industriale, Politecnico di Milano, Milan, Italy; supported by a NATO fellowship.

  • ** Fellow of the National Institute of General Medical Sciences, 1967-1968. Present address: Union Carbide Technical Center, South Charleston, West Virginia 25303.

  • * The work described in this paper was sponsored in part by the U.S. Atomic Energy Commission.

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