ON THE CONFORMATIONS OF HALLUCINOGENIC MOLECULES AND THEIR CORRELATION

  1. Cyrus Chothia and
  2. Peter Pauling
  1. WILLIAM RAMSAY LABORATORY, UNIVERSITY COLLEGE LONDON, ENGLAND
  2. RALPH FORSTER LABORATORY, UNIVERSITY COLLEGE LONDON, ENGLAND

Abstract

There are only a few possible conformations of D-lysergic acid diethylamide and hallucinogenic derivatives of tryptamine and phenylethylamine. Of these possible conformations there is a high structural correlation among the probable conformations of active hallucinogenic molecules and between these conformations and the known conformations of several central nervous system transmitter molecules.

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