MECHANISM OF PROFLAVIN MUTAGENESIS*

  1. Anand Sarabhai† and
  2. Hildegard Lamfrom
  1. INSTITUTE OF MOLECULAR BIOLOGY, UNIVERSITY OF OREGON, EUGENE

Abstract

The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.

Footnotes

  • ↵ † Fellow of the Jane Coffin Childs Memorial Fund for Medical Research.

  • ↵ * This work was supported by National Science Foundation grants GB 8109 (F. W. Stahl) and GB 7116 (G. Streisinger) and U.S. Public Health Service grants GM 15423-02 and GM-00715-10 (A. Novick).

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  1. PNAS 1969-08 vol. 63 no. 4 1196-1197
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