RADICAL TRANSFORMATION IN IRRADIATED DNA AND ITS CONSTITUENTS

  1. J. N. Herak and
  2. V. Galogaza
  1. INSTITUTE “RUDJER BO̊SKOVIĆ,” ZAGREB, CROATIA, YUGOSLAVIA

Abstract

Electron spin resonance spectroscopy has been used to study transformation of radicals in DNA and a number of its constituents. It was found that in all the bases irradiated at 77°K, hydrogen-addition radicals were formed on warming. The following mechanism of radical transformation has been proposed: damaged species, probably ion-radicals, release hydrogen atoms on warming, which then add to the undamaged bases, preferentially thymine. Thymine need not be the place of the primary damage.

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  1. PNAS 1969-09 vol. 64 no. 1 8-12
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