A MUTATION WHICH CHANGES A MEMBRANE PROTEIN OF E. coli*

  1. Masayori Inouye and
  2. J. Peter Guthrie
  1. PROGRAM IN BIOCHEMICAL SCIENCES, MOFFETT LABORATORY, PRINCETON UNIVERSITY, PRINCETON, NEW JERSEY

Abstract

A temperature-sensitive mutant of E. coli, which cannot synthesize DNA at high temperature but can continue cell division, shows a difference in a membrane protein fraction at high temperature by gel electrophoresis. This mutation of a bacterial membrane protein is unique. The protein may link DNA replication and cell division through the membrane.

Footnotes

  • * This work was aided by grant A1-04409 from the U.S. Public Health Service to Dr. A. B. Pardee and by a National Research Council of Canada postdoctoral fellowship to J. P. G.

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