Mechanism of Action of Thrombin on Fibrinogen, I. Synthesis of Fibrinogen-like Peptides, and Their Proteolysis by Thrombin and Trypsin

  1. Rudolf H. Andreatta*,
  2. Ronald K. H. Liem†, and
  3. Harold A. Scheraga‡
  1. 1Department of Chemistry, Cornell University, Ithaca, New York 14850

Abstract

In a study of the action of thrombin on fibrinogen and a comparison of this enzyme with trypsin, several fibrinogen-like oligopeptides were synthesized. The hydrolysis of the arginyl-glycine bond in these peptides, by both of these enzymes, is examined and compared.

Footnotes

  • ↵ * Present address: c/o J. R. Geigy S.A., Central Research, CH-4000, Basel 21, Switzerland.

  • ↵ † Todd Fellow 1969-1971.

  • ↵ ‡ To whom requests for reprints should be addressed.

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  1. PNAS 1971-02 vol. 68 no. 2 253-256
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