Selective Condensation of Aminoacyl Adenylates by Nucleoproteinoid Microparticles

  1. Tadayoshi Nakashima and
  2. Sidney W. Fox
  1. Institute of Molecular Evolution, University of Miami, Coral Gables, Florida 33134
  2. Department of Biochemistry, University of Miami, Coral Gables, Florida 33134

Abstract

Microparticles composed of each of four enzymically synthesized homopolynucleotides and the same lysine-rich proteinoid have been found to influence the condensation of the AMP-anhydrides of each of four amino acids. The conditions of preparation of the particles and other variables of the experiments control the types of reaction. When a specified set of conditions was identified empirically, the incorporation favored the amino acids whose present-day codons are related to the homopolynucleotide in the particle.

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  1. PNAS 1972-01 vol. 69 no. 1 106-108
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