Cell Separation on Affinity Columns: The Isolation of Immunospecific Precursor Cells from Unimmunized Mice

  1. Claudia Henry*,
  2. John Kimura, and
  3. Leon Wofsy†
  1. Department of Bacteriology and Immunology, University of California, Berkeley, Calif. 94720
  2. *Section of Hematology and Immunology, Department of Medicine, University of California, San Francisco, Calif. 94122

Abstract

We have used affinity columns to isolate from the spleens of unimmunized mice a population of lymphocytes that specifically bind a lactoside hapten. These cells are able to initiate an antibody response to azophenyl-β-lactoside when transferred to appropriate irradiated recipients.

Footnotes

  • ↵ † To whom requests for reprints should be addressed.

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  1. PNAS January 1, 1972 vol. 69 no. 1 34-36
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