Mammalian Cells with Altered Forms of RNA Polymerase II

  1. V. L. Chan*,
  2. G. F. Whitmore, and
  3. Louis Siminovitch
  1. Departments of Medical Cell Biology and Medical Biophysics, University of Toronto, and The Ontario Cancer Institute, Toronto, Canada
  2. *Department of Biochemistry, University of Malaya, Kuala Lumpur, Malaysia

Abstract

Mutants of Chinese hamster ovary cells that are resistant to α-amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to α-amanitin. These results indicate that mutation to α-amanitin resistance involves a change of a structural gene.

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  1. PNAS 1972-11 vol. 69 no. 11 3119-3123
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