Control of the Synthesis of Fatty-Acid Synthetase in Rat Liver by Insulin, Glucagon, and Adenosine 3′:5′ Cyclic Monophosphate

  1. M. R. Lakshmanan,
  2. Carl M. Nepokroeff, and
  3. John W. Porter
  1. Lipid Metabolism Laboratory, Veterans Administration Hospital, Madison, Wis. 53706
  2. Department of Physiological Chemistry, University of Wisconsin, Madison, Wis. 53706

Abstract

The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.

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  1. PNAS 1972-12 vol. 69 no. 12 3516-3519
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