On the Identity of DOPA Decarboxylase and 5-Hydroxytryptophan Decarboxylase

  1. James G. Christenson,
  2. Wallace Dairman, and
  3. Sidney Udenfriend
  1. 1Roche Institute of Molecular Biology, Nutley, New Jersey 07110

Abstract

Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.

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