Cytochalasin B: Inhibition of Glucose and Glucosamine Transport*

  1. Richard D. Estensen and
  2. Peter G. W. Plagemann
  1. Department of Pathology, Medical School, University of Minnesota, Minneapolis, Minn. 55455
  2. Department of Microbiology, Medical School, University of Minnesota, Minneapolis, Minn. 55455

Abstract

Cytochalasin B has been shown to potently inhibit the transport of glucose, deoxyglucose, and glucosamine by Novikoff hepatoma cells in suspension culture without affecting their intracellular phosphorylation and metabolism. Deoxyglucose transport is inhibited by cytochalasin B in a simple competitive manner. Although this inhibition is not sufficient to explain the biological action of the drug on cytokinesis, it does explain earlier observations on inhibition by cytochalasin B of the incorporation of glucose and glucosamine, and probably of other extracellular precursors, into macromolecules by various types of cells.

Footnotes

  • ↵ * This is no. V in a series of papers. No. IV of the series is Becker, E. L., Davis, A. T., Estensen, R. D. & Quie, P. G., J. Immunol., 108, 396.

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  1. PNAS 1972-06 vol. 69 no. 6 1430-1434
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