Growth Control in Cultured Mouse Fibroblasts: Induction of the Pleiotypic and Mitogenic Responses by a Purified Growth Factor

  1. P. S. Rudland*,
  2. W. Seifert, and
  3. D. Gospondarowicz
  1. 1The Salk Institute for Biological Studies, P.O. Box 1809, San Diego, California 92112

Abstract

Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.

Footnotes

  • ↵ * Present address: Division of Cell Regulation, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's Inn Fields, London, WC2A 3PX, England.

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  1. PNAS 1974-07 vol. 71 no. 7 2600-2604
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