Biological Activity of a Growth Factor for Ovarian Cells
- Department of Pediatrics, University of California at San Diego, La Jolla, California 92037
- Department of Biology, University of California at San Diego, La Jolla, California 92037
- Department of Molecular Endocrinology, The Salk Institute for Biological Studies, P.O. Box 1809, San Diego, California 92112
Abstract
The biological activity of a protein growth factor is described. This factor was isolated from bovine pituitary tissue, and its activity was tested on cells of rat ovarian origin. Activity was assayed as growth-promoting potential measured by cell counts and is concentrationdependent. Similar growth stimulation was not produced by several cyclic nucleotides tested, neither was there crossreactivity between this growth factor and a chemically similar one produced by rat liver cells.
