A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

  1. Werner A. Klee and
  2. Marshall Nirenberg
  1. Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014
  2. Laboratory of Biochemical Genetics, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

A neuroblastoma × glioma hybrid cell line with well-developed neural properties was found that has high-affinity morphine receptors. The average cell contains approximately 3 × 106 receptors. In contrast, parent cells and other neuroblastoma or hybrid cell lines tested had few or no morphine receptors.

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  1. PNAS 1974-09 vol. 71 no. 9 3474-3477
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