Crystallization of a common cold virus, human rhinovirus 14: “Isomorphism” with poliovirus crystals

  1. John W. Erickson*,
  2. Elizabeth A. Frankenberger*,
  3. Michael G. Rossmann*,†,
  4. G. Shay Fout‡,
  5. K. C. Medappa‡, and
  6. Roland R. Rueckert‡
  1. *Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907
  2. ‡Biophysics Laboratory and Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706

Abstract

Crystals of rhinovirus 14 have been grown reproducibly. They diffract x-rays to a resolution of at least 3.5 Å. The orthorhombic crystal unit cell contains two virions, each situated on a crystallographic twofold axis. At less than 30-Å resolution, the space group approximates to 1222 with the particles possessing 222 pseudo crystallographic symmetry. The crystals are “isomorphous” with type I polio crystals [Finch, J. T. & Klug, A. (1959) Nature (London) 183, 1709-1714; Hogle, J. M. (1982) J. Mol. Biol. 160, 663-668], suggesting some similarities of structure between enteroviruses and rhinoviruses.

Footnotes

  • ↵ † To whom reprint requests should be addressed.

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  1. PNAS 1983-02 vol. 80 no. 4 931-934
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