Derivation of the relation between the linear Onsager coefficients and the equilibrium one-way cycle fluxes of a biochemical kinetic diagram

Abstract

The Onsager flux-force coefficients L_ij for any biochemical system at a steady state near equilibrium have a simple interpretation: they are linear combinations of the equilibrium one-way cycle fluxes of the kinetic diagram for the system. An explicit and general expression for L_ij is derived. This supplements the more pedagogical argument published elsewhere, which was based on a particular special case.

• enzyme kinetics
• flux-force relation
• near-equilibrium steady state
• irreversible thermodynamics