A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human)

  1. G P Schwartz,
  2. G T Burke, and
  3. P G Katsoyannis
  1. Department of Biochemistry, Mount Sinai School of Medicine, City University of New York, NY 10029.

Abstract

An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.

« Previous | Next Article »Table of Contents

This Article

  1. PNAS 1989-01 vol. 86 no. 2 458-461
  1. » Abstract
  2. Full Text (PDF)

Classifications

About Our New Site Design >>
Link: Advanced Search

This Week's Issue

  1. July 22, 2008, 105 (29)
  1. Current Issue
  1. Alert me to new issues of PNAS

Most