Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum

  1. L Molina Y Vedia and
  2. E G Lapetina
  1. Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC 27709.

Abstract

We have observed that iloprost, a prostacyclin analog, causes the translocation of a 23-kDa protein from the membrane to the cytosol of human platelets. This 23-kDa protein is recognized by a Gs alpha (alpha subunit of stimulatory guanine nucleotide binding regulatory protein) antiserum but is not ADP-ribosylated by cholera toxin. The translocation of the Gs alpha-related protein might be an important part of the complex chain of events resulting in agonist-induced desensitization.

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  1. PNAS 1989-02 vol. 86 no. 3 868-870
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