PNAS central -- Submit and Review Online Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search



This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tyson, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tyson, J. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

Proceedings of the National Academy of Sciences, Vol 88, 7328-7332, Copyright © 1991 by National Academy of Sciences

ARTICLE

Modeling the Cell Division Cycle: cdc2 and Cyclin Interactions

JJ Tyson

The proteins cdc2 and cyclin form a heterodimer (maturation promoting factor) that controls the major events of the cell cycle. A mathematical model for the interactions of cdc2 and cyclin is constructed. Simulation and analysis of the model show that the control system can operate in three modes: as a steady state with high maturation promoting factor activity, as a spontaneous oscillator, or as an excitable switch. We associate the steady state with metaphase arrest in unfertilized eggs, the spontaneous oscillations with rapid division cycles in early embryos, and the excitable switch with growth-controlled division cycles typical of nonembryonic cells.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Biophys. JHome page
B. Han and J. Wang
Quantifying Robustness and Dissipation Cost of Yeast Cell Cycle Network: The Funneled Energy Landscape Perspectives
Biophys. J., June 1, 2007; 92(11): 3755 - 3763.
[Abstract] [Full Text] [PDF]

Home page
 Brief BioinformHome page
D. Gilbert, H. Fuss, X. Gu, R. Orton, S. Robinson, V. Vyshemirsky, M. J. Kurth, C. S. Downes, and W. Dubitzky
Computational methodologies for modelling, analysis and simulation of signalling networks
Brief Bioinform, December 1, 2006; 7(4): 339 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. Csikasz-Nagy, D. Battogtokh, K. C. Chen, B. Novak, and J. J. Tyson
Analysis of a Generic Model of Eukaryotic Cell-Cycle Regulation
Biophys. J., June 15, 2006; 90(12): 4361 - 4379.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
Z. Han, L. Yang, W. R. MacLellan, J. N. Weiss, and Z. Qu
Hysteresis and Cell Cycle Transitions: How Crucial Is It?
Biophys. J., March 1, 2005; 88(3): 1626 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W. Sha, J. Moore, K. Chen, A. D. Lassaletta, C.-S. Yi, J. J. Tyson, and J. C. Sible
From the Cover: Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts
PNAS, February 4, 2003; 100(3): 975 - 980.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
B Novak and J. Tyson
Numerical analysis of a comprehensive model of M-phase control in Xenopus oocyte extracts and intact embryos
J. Cell Sci., December 1, 1993; 106(4): 1153 - 1168.
[Abstract] [PDF]