Keystone Symposia 2008 Conference Schedule Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search



This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (91)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nikolov, D. B.
Right arrow Articles by Burley, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nikolov, D. B.
Right arrow Articles by Burley, S. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 15-22, January 1997

Review

RNA polymerase II transcription initiation: A structural view

D. B. Nikolov*, and S. K. Burley*Dagger

* Laboratories of Molecular Biophysics and Dagger  Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021

In eukaryotes, RNA polymerase II transcribes messenger RNAs and several small nuclear RNAs. Like RNA polymerases I and III, polymerase II cannot act alone. Instead, general initiation factors [transcription factor (TF) IIB, TFIID, TFIIE, TFIIF, and TFIIH] assemble on promoter DNA with polymerase II, creating a large multiprotein-DNA complex that supports accurate initiation. Another group of accessory factors, transcriptional activators and coactivators, regulate the rate of RNA synthesis from each gene in response to various developmental and environmental signals. Our current knowledge of this complex macromolecular machinery is reviewed in detail, with particular emphasis on insights gained from structural studies of transcription factors.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Protein Sci.Home page
S. Akashi, S. Nagakura, S. Yamamoto, M. Okuda, Y. Ohkuma, and Y. Nishimura
Structural characterization of human general transcription factor TFIIF in solution
Protein Sci., March 1, 2008; 17(3): 389 - 400.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. V. Glenn, J. R. Beattie, L. Barrett, N. Frizzell, S. R. Thorpe, M. E Boulton, J. J. McGarvey, and A. W. Stitt
Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging
FASEB J, November 1, 2007; 21(13): 3542 - 3552.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Panebra, M. R. Schwarb, C. B. Glinka, and S. B. Liggett
Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L453 - L462.
[Abstract] [Full Text] [PDF]

Home page
 Genome Res.Home page
Z. D. Zhang, A. Paccanaro, Y. Fu, S. Weissman, Z. Weng, J. Chang, M. Snyder, and M. B. Gerstein
Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions
Genome Res., June 1, 2007; 17(6): 787 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Su, D. Lee, B. Ganss, and J. Sodek
Stereochemical Analysis of the Functional Significance of the Conserved Inverted CCAAT and TATA Elements in the Rat Bone Sialoprotein Gene Promoter
J. Biol. Chem., April 14, 2006; 281(15): 9882 - 9890.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
A. W. STITT
The Maillard Reaction in Eye Diseases
Ann. N.Y. Acad. Sci., June 1, 2005; 1043(1): 582 - 597.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
N. I. Gershenzon and I. P. Ioshikhes
Synergy of human Pol II core promoter elements revealed by statistical sequence analysis
Bioinformatics, April 15, 2005; 21(8): 1295 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J.-M. Tsai, H.-C. Wang, J.-H. Leu, H.-H. Hsiao, A. H.-J. Wang, G.-H. Kou, and C.-F. Lo
Genomic and Proteomic Analysis of Thirty-Nine Structural Proteins of Shrimp White Spot Syndrome Virus
J. Virol., October 15, 2004; 78(20): 11360 - 11370.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Eriksson, D. Biswas, Y. Yu, J. M. Stewart, and D. J. Stillman
TATA-Binding Protein Mutants That Are Lethal in the Absence of the Nhp6 High-Mobility-Group Protein
Mol. Cell. Biol., July 15, 2004; 24(14): 6419 - 6429.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. Vigneault, S. McGraw, L. Massicotte, and M.-A. Sirard
Transcription Factor Expression Patterns in Bovine In Vitro-Derived Embryos Priorto Maternal-Zygotic Transition
Biol Reprod, June 1, 2004; 70(6): 1701 - 1709.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Monslow, J. D. Williams, C. A. Guy, I. K. Price, K. J. Craig, H. J. Williams, N. M. Williams, J. Martin, S. L. Coleman, N. Topley, et al.
Identification and Analysis of the Promoter Region of the Human Hyaluronan Synthase 2 Gene
J. Biol. Chem., May 14, 2004; 279(20): 20576 - 20581.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
W. R. Hartman and P. Hentosh
The Antileukemia Drug 2-Chloro-2'-deoxyadenosine: An Intrinsic Transcriptional Antagonist
Mol. Pharmacol., January 1, 2004; 65(1): 227 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
S. Rombauts, K. Florquin, M. Lescot, K. Marchal, P. Rouze, and Y. Van de Peer
Computational Approaches to Identify Promoters and cis-Regulatory Elements in Plant Genomes
Plant Physiology, July 1, 2003; 132(3): 1162 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
B. L. Hanzelka, T. J. Darcy, and J. N. Reeve
TFE, an Archaeal Transcription Factor in Methanobacterium thermoautotrophicum Related to Eucaryal Transcription Factor TFIIE{alpha}
J. Bacteriol., March 1, 2001; 183(5): 1813 - 1818.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
M. G. Anderson, K. E. S. Scoggin, C. M. Simbulan-Rosenthal, and J. A. Steadman
Identification of Poly(ADP-Ribose) Polymerase as a Transcriptional Coactivator of the Human T-Cell Leukemia Virus Type 1 Tax Protein
J. Virol., March 1, 2000; 74(5): 2169 - 2177.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
P. A. Moore, J. Ozer, M. Salunek, G. Jan, D. Zerby, S. Campbell, and P. M. Lieberman
A Human TATA Binding Protein-Related Protein with Altered DNA Binding Specificity Inhibits Transcription from Multiple Promoters and Activators
Mol. Cell. Biol., November 1, 1999; 19(11): 7610 - 7620.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. D. Lalioti, H. S. Scott, and S. E. Antonarakis
Altered spacing of promoter elements due to the dodecamer repeat expansion contributes to reduced expression of the cystatin B gene in EPM1
Hum. Mol. Genet., September 1, 1999; 8(9): 1791 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. C. Kyrpides and C. A. Ouzounis
Transcription in Archaea
PNAS, July 20, 1999; 96(15): 8545 - 8550.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
T. J. Darcy, W. Hausner, D. E. Awery, A. M. Edwards, M. Thomm, and J. N. Reeve
Methanobacterium thermoautotrophicum RNA Polymerase and Transcription In Vitro
J. Bacteriol., July 15, 1999; 181(14): 4424 - 4429.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
R. T. Ranallo, K. Struhl, and L. A. Stargell
A TATA-Binding Protein Mutant Defective for TFIID Complex Formation In Vivo
Mol. Cell. Biol., June 1, 1999; 19(6): 3951 - 3957.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Ioshikhes, E. N. Trifonov, and M. Q. Zhang
Periodical distribution of transcription factor sites in promoter regions and connection with chromatin structure
PNAS, March 16, 1999; 96(6): 2891 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Syntichaki and G. Thireos
The Gcn5·Ada Complex Potentiates the Histone Acetyltransferase Activity of Gcn5
J. Biol. Chem., September 18, 1998; 273(38): 24414 - 24419.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Singh and J. B. Rogers
The Novel Core Promoter Element GAAC in the hgl5 Gene of Entamoeba histolytica Is Able to Direct a Transcription Start Site Independent of TATA or Initiator Regions
J. Biol. Chem., August 21, 1998; 273(34): 21663 - 21668.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Okamoto, S. Yamamoto, Y. Watanabe, T. Ohta, F. Hanaoka, R. G. Roeder, and Y. Ohkuma
Analysis of the Role of TFIIE in Transcriptional Regulation through Structure-Function Studies of the TFIIEbeta Subunit
J. Biol. Chem., July 31, 1998; 273(31): 19866 - 19876.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Yokomori, C. P. Verrijzer, and R. Tjian
An interplay between TATA box-binding protein and transcription factors IIE and IIA modulates DNA binding and transcription
PNAS, June 9, 1998; 95(12): 6722 - 6727.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
M. Hampsey
Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery
Microbiol. Mol. Biol. Rev., June 1, 1998; 62(2): 465 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
W. Schul, R. van Driel, and L. de Jong
Coiled Bodies and U2 snRNA Genes Adjacent to Coiled Bodies Are Enriched in Factors Required for snRNA Transcription
Mol. Biol. Cell, May 1, 1998; 9(5): 1025 - 1036.
[Abstract] [Full Text]

Home page
 J. Bacteriol.Home page
P. Leng, P. E. Carter, and A. J. P. Brown
The TATA-Binding Protein (TBP) from the Human Fungal Pathogen Candida albicans Can Complement Defects in Human and Yeast TBPs
J. Bacteriol., April 1, 1998; 180(7): 1771 - 1776.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
Y. Shen, G. A. Kassavetis, G. O. Bryant, and A. J. Berk
Polymerase (Pol) III TATA Box-Binding Protein (TBP)-Associated Factor Brf Binds to a Surface on TBP Also Required for Activated Pol II Transcription
Mol. Cell. Biol., March 1, 1998; 18(3): 1692 - 1700.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
T. Lagrange, A. N. Kapanidis, H. Tang, D. Reinberg, and R. H. Ebright
New core promoter element in RNA polymerase II-dependent transcription: sequence-specific DNA binding by transcription factor IIB
Genes & Dev., January 1, 1998; 12(1): 34 - 44.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T.-K. Kim, T. Lagrange, Y.-H. Wang, J. D. Griffith, D. Reinberg, and R. H. Ebright
Trajectory of DNA in the RNA polymerase II transcription preinitiation complex
PNAS, November 11, 1997; 94(23): 12268 - 12273.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. L. Pereira, R. A. Grayling, R. Lurz, and J. N. Reeve
Archaeal nucleosomes
PNAS, November 11, 1997; 94(23): 12633 - 12637.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
U. Singh, J. B. Rogers, B. J. Mann, and W. A. Petri Jr.
Transcription initiation is controlled by three core promoter elements in the hgl5 gene of the protozoan parasite Entamoeba histolytica
PNAS, August 5, 1997; 94(16): 8812 - 8817.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Widlak, R. B. Gaynor, and W. T. Garrard
In Vitro Chromatin Assembly of the HIV-1 Promoter. ATP-DEPENDENT POLAR REPOSITIONING OF NUCLEOSOMES BY Sp1 AND NFkappa B
J. Biol. Chem., July 11, 1997; 272(28): 17654 - 17661.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Forget, F. Robert, G. Grondin, Z. F. Burton, J. Greenblatt, and B. Coulombe
RAP74 induces promoter contacts by RNA polymerase II upstream and downstream of a DNA bend centered on the TATA box
PNAS, July 8, 1997; 94(14): 7150 - 7155.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. Wei, D. Dorjsuren, Y. Lin, W. Qin, T. Nomura, N. Hayashi, and S. Murakami
Direct Interaction between the Subunit RAP30 of Transcription Factor IIF (TFIIF) and RNA Polymerase Subunit 5, Which Contributes to the Association between TFIIF and RNA Polymerase II
J. Biol. Chem., April 6, 2001; 276(15): 12266 - 12273.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Das and W. M. Scovell
The Binding Interaction of HMG-1 with the TATA-binding Protein/TATA Complex
J. Biol. Chem., August 24, 2001; 276(35): 32597 - 32605.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
U. Banik, J. M. Beechem, E. Klebanow, S. Schroeder, and P. A. Weil
Fluorescence-based Analyses of the Effects of Full-length Recombinant TAF130p on the Interaction of TATA Box-binding Protein with TATA Box DNA
J. Biol. Chem., December 21, 2001; 276(52): 49100 - 49109.
[Abstract] [Full Text] [PDF]