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* Ludwig Institute for Cancer Research, Imperial College School of
Medicine at St. Mary's, Norfolk Place, London, W2 1PG, United Kingdom;
Communicated by Walter Bodmer, Imperial Cancer Research Fund,
Oxford, United Kingdom, March 25, 1997
(received for review November 26, 1996)
The expression of cyclin-dependent kinase inhibitor
p27kip1 in human tumors and normal tissues was investigated
using a panel of novel anti-p27kip1 mAbs. An inverse
correlation between expression of p27kip1 and cell
proliferation was generally observed after analyzing its expression in
25 different normal human tissues. In some highly proliferative human
breast cancer cells, however, high level p27kip1 expression
was seen, indicating the existence of a mechanism by which some growing
tumor cells may tolerate this inhibitor of cell cycle progression.
Detailed studies demonstrated a correlation between the high level
expression of p27kip1 and cyclin D1 in human breast cancer
cells. There was also an inverse correlation between the expression of
p27kip1 and the degree of tumor malignancy in human breast
and colorectal cancers, indicating that p27kip1 may be a
useful prognostic marker in these cancers.
Proc. Natl. Acad. Sci. USA
Vol. 94,
pp. 6380-6385,
June 1997
Medical Sciences
High level expression of p27kip1 and cyclin D1 in
some human breast cancer cells: Inverse correlation between the
expression of p27kip1 and degree of malignancy in human
breast and colorectal cancers
,
,
,,,, and Ludwig Institute for Cancer Research, Courtauld Building, 91 Riding House Street, London, W1P 8BT, United Kingdom;
Department of Molecular & Cellular Pathology, University of
Dundee, Dundee, DD1 9SY, United Kingdom; § Clinical Oncology
Unit, Imperial Cancer Research Fund, Guy's Hospital, London, SE1 9RT,
United Kingdom; ¶ Department of Pathology, University of
Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, United
Kingdom; and Department of Histopathology, Charing Cross
Hospital, Fulham Palace Road, London, W6 8RF, United Kingdom
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R. S. Muraoka, A. E.G. Lenferink, J. Simpson, D. M. Brantley, L. R. Roebuck, F. M. Yakes, and C. L. Arteaga Cyclin-dependent Kinase Inhibitor p27Kip1 Is Required for Mouse Mammary Gland Morphogenesis and Function J. Cell Biol., May 21, 2001; 153(5): 917 - 932. [Abstract] [Full Text] [PDF]
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