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Proc. Natl. Acad. Sci. USA
Vol. 94, pp. 7612-7616, July 1997
Neurobiology

Aggregation and disaggregation of senile plaques in Alzheimer disease

L. Cruz*, B. Urbanc*, S. V. Buldyrev*, R. Christiedagger , T. Gómez-Isladagger , S. HavlinDagger , M. McNamaradagger , H. E. Stanley*,, and B. T. Hymandagger

* Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215; dagger  Neurology Service, Massachusetts General Hospital, Boston, MA 02114; and Dagger  Gonda-Goldschmied Center and Department of Physics, Bar-Ilan University, Ramat-Gan, 52900 Israel

Communicated by Herman Z. Cummins, City College of the City University of New York, New York, NY, May 7, 1997 (received for review March 14, 1997)

We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried out the quantitative analysis using statistical methods to gain insights about the processes that govern Abeta peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing Abeta deposits to diffuse over the surface of plaques.


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