Previous Article |
Table of Contents
| Next Article 
Laboratory of Persistent Viral Diseases, Rocky Mountain
Laboratories, National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Hamilton, MT 59840
Friend virus infection of adult immunocompetent mice is a
well established model for studying genetic resistance to infection by
an immunosuppressive retrovirus. This paper reviews both the genetics
of immune resistance and the types of immune responses required for
recovery from infection. Specific major histocompatibility complex
(MHC) class I and II alleles are necessary for recovery, as is a
non-MHC gene, Rfv-3, which controls virus-specific antibody responses.
In concordance with these genetic requirements are immunological
requirements for cytotoxic T lymphocyte, T helper, and antibody
responses, each of which provides essential nonoverlapping functions.
The complexity of responses necessary for recovery from Friend virus
infection has implications for both immunotherapies and vaccines. For
example, it is shown that successful passive antibody therapy is
dependent on MHC type because of the requirement for T cell responses.
For vaccines, successful immunization requires priming of both T cell
and B cell responses. In vivo depletion experiments
demonstrate different requirements for CD8+ T cells
depending on the vaccine used. The implications of these studies for
human retroviral diseases are discussed.
Proc. Natl. Acad. Sci. USA
Vol. 94,
pp. 7811-7816,
July 1997
Review
Immunity to retroviral infection: The Friend virus model
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg What's this?
This article has been cited by other articles in HighWire Press-hosted journals:
|
|
 |
|
  S. Balkow, F. Krux, K. Loser, J. U. Becker, S. Grabbe, and U. Dittmer Friend retrovirus infection of myeloid dendritic cells impairs maturation, prolongs contact to naive T cells, and favors expansion of regulatory T cells Blood, December 1, 2007; 110(12): 3949 - 3958. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schneider-Schaulies and U. Dittmer Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression J. Gen. Virol., June 1, 2006; 87(6): 1423 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. He, R. J. Messer, S. Sakaguchi, G. Yang, S. J. Robertson, and K. J. Hasenkrug Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection J. Virol., November 1, 2004; 78(21): 11641 - 11647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Yap, S. Nisole, C. Lynch, and J. P. Stoye Trim5{alpha} protein restricts both HIV-1 and murine leukemia virus PNAS, July 20, 2004; 101(29): 10786 - 10791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sugahara, S. Tsuji-Kawahara, and M. Miyazawa Identification of a Protective CD4+ T-Cell Epitope in p15gag of Friend Murine Leukemia Virus and Role of the MA Protein Targeting the Plasma Membrane in Immunogenicity J. Virol., June 15, 2004; 78(12): 6322 - 6334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Peterson, I. Stromnes, R. Messer, K. Hasenkrug, and B. Chesebro Novel Role of CD8+ T Cells and Major Histocompatibility Complex Class I Genes in the Generation of Protective CD4+ Th1 Responses during Retrovirus Infection in Mice J. Virol., July 17, 2002; 76(16): 7942 - 7948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Dittmer, B. Race, K. E. Peterson, I. M. Stromnes, R. J. Messer, and K. J. Hasenkrug Essential Roles for CD8+ T Cells and Gamma Interferon in Protection of Mice against Retrovirus-Induced Immunosuppression J. Virol., January 1, 2002; 76(1): 450 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Thach, S. R. Kleeberger, P. C. Tucker, and D. E. Griffin Genetic Control of Neuroadapted Sindbis Virus Replication in Female Mice Maps to Chromosome 2 and Associates with Paralysis and Mortality J. Virol., September 15, 2001; 75(18): 8674 - 8680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Bruland, H. Y. Dai, L. A. S. Lavik, L. I. Kristiansen, and A. Dalen Gender-related differences in susceptibility, early virus dissemination and immunosuppression in mice infected with Friend murine leukaemia virus variant FIS-2 J. Gen. Virol., August 1, 2001; 82(8): 1821 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iwashiro, R. J. Messer, K. E. Peterson, I. M. Stromnes, T. Sugie, and K. J. Hasenkrug Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection PNAS, July 13, 2001; (2001) 151174198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Strestik, A. R. M. Olbrich, K. J. Hasenkrug, and U. Dittmer The role of IL-5, IL-6 and IL-10 in primary and vaccine-primed immune responses to infection with Friend retrovirus (Murine leukaemia virus) J. Gen. Virol., June 1, 2001; 82(6): 1349 - 1354. [Abstract] [Full Text]
|
|
|
|
|
|
P. L. Earl, W. Sugiura, D. C. Montefiori, C. C. Broder, S. A. Lee, C. Wild, J. Lifson, and B. Moss Immunogenicity and Protective Efficacy of Oligomeric Human Immunodeficiency Virus Type 1 gp140 J. Virol., January 15, 2001; 75(2): 645 - 653. [Abstract] [Full Text]
|
|
|
|
|
|
U. Dittmer, K. E. Peterson, R. Messer, I. M. Stromnes, B. Race, and K. J. Hasenkrug Role of Interleukin-4 (IL-4), IL-12, and Gamma Interferon in Primary and Vaccine-Primed Immune Responses to Friend Retrovirus Infection J. Virol., January 15, 2001; 75(2): 654 - 660. [Abstract] [Full Text]
|
|
|
|
|
|
M. Iwashiro, K. Peterson, R. J. Messer, I. M. Stromnes, and K. J. Hasenkrug CD4+ T Cells and Gamma Interferon in the Long-Term Control of Persistent Friend Retrovirus Infection J. Virol., January 1, 2001; 75(1): 52 - 60. [Abstract] [Full Text]
|
|
|
|
|
|
P. A. Ney and A. D. D'Andrea Friend erythroleukemia revisited Blood, December 1, 2000; 96(12): 3675 - 3680. [Full Text] [PDF]
|
|
|
|
|
|
G. Towers, M. Bock, S. Martin, Y. Takeuchi, J. P. Stoye, and O. Danos A conserved mechanism of retrovirus restriction in mammals PNAS, October 4, 2000; (2000) 200286297. [Abstract] [Full Text]
|
|
|
|
|
|
M. Bock, K. N. Bishop, G. Towers, and J. P. Stoye Use of a Transient Assay for Studying the Genetic Determinants of Fv1 Restriction J. Virol., August 15, 2000; 74(16): 7422 - 7430. [Abstract] [Full Text]
|
|
|
|
|
|
K. E. Peterson, M. Iwashiro, K. J. Hasenkrug, and B. Chesebro Major Histocompatibility Complex Class I Gene Controls the Generation of Gamma Interferon-Producing CD4+ and CD8+ T Cells Important for Recovery from Friend Retrovirus-Induced Leukemia J. Virol., June 1, 2000; 74(11): 5363 - 5367. [Abstract] [Full Text]
|
|
|
|
|
|
V. Panoutsakopoulou, K. Hunter, T. G. Sieck, E. P. Blankenhorn, and K. J. Blank Genetic Regulation of Long-Term Nonprogression in E-55+ Murine Leukemia Virus Infection in Mice J. Virol., November 1, 1999; 73(11): 9232 - 9236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Dittmer, B. Race, and K. J. Hasenkrug Kinetics of the Development of Protective Immunity in Mice Vaccinated with a Live Attenuated Retrovirus J. Virol., October 1, 1999; 73(10): 8435 - 8440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Super, K. J. Hasenkrug, S. Simmons, D. M. Brooks, R. Konzek, K. D. Sarge, R. I. Morimoto, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, et al. Fine Mapping of the Friend Retrovirus Resistance Gene, Rfv3, on Mouse Chromosome 15 J. Virol., September 1, 1999; 73(9): 7848 - 7852. [Abstract] [Full Text]
|
|
|
|
|
|
J. R. Mascola, M. G. Lewis, G. Stiegler, D. Harris, T. C. VanCott, D. Hayes, M. K. Louder, C. R. Brown, C. V. Sapan, S. S. Frankel, et al. Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies J. Virol., May 1, 1999; 73(5): 4009 - 4018. [Abstract] [Full Text]
|
|
|
|
|
|
G. Milan, A. Zambon, M. Cavinato, P. Zanovello, A. Rosato, and D. Collavo Dissecting the Immune Response to Moloney Murine Sarcoma/Leukemia Virus-Induced Tumors by Means of a DNA Vaccination Approach J. Virol., March 1, 1999; 73(3): 2280 - 2287. [Abstract] [Full Text]
|
|
|
|
|
|
P. Mazzetti, S. Giannecchini, D. Del Mauro, D. Matteucci, P. Portincasa, A. Merico, C. Chezzi, and M. Bendinelli AIDS Vaccination Studies Using an Ex Vivo Feline Immunodeficiency Virus Model: Detailed Analysis of the Humoral Immune Response to a Protective Vaccine J. Virol., January 1, 1999; 73(1): 1 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Super, D. Brooks, K. Hasenkrug, and B. Chesebro Requirement for CD4+ T Cells in the Friend Murine Retrovirus Neutralizing Antibody Response: Evidence for Functional T Cells in Genetic Low-Recovery Mice J. Virol., November 1, 1998; 72(11): 9400 - 9403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Dittmer, D. M. Brooks, and K. J. Hasenkrug Characterization of a Live-Attenuated Retroviral Vaccine Demonstrates Protection via Immune Mechanisms J. Virol., August 1, 1998; 72(8): 6554 - 6558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Hasenkrug, D. M. Brooks, and U. Dittmer Critical Role for CD4+ T Cells in Controlling Retrovirus Replication and Spread in Persistently Infected Mice J. Virol., August 1, 1998; 72(8): 6559 - 6564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y. Dai, G. I. Troseth, M. Gunleksrud, T. Bruland, L. A. Solberg, H. Aarset, L. I. Kristiansen, and A. Dalen Identification of Genetic Determinants Responsible for the Rapid Immunosuppressive Activity and the Low Leukemogenic Potential of a Variant of Friend Leukemia Virus, FIS-2 J. Virol., February 1, 1998; 72(2): 1244 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iwashiro, R. J. Messer, K. E. Peterson, I. M. Stromnes, T. Sugie, and K. J. Hasenkrug Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection PNAS, July 31, 2001; 98(16): 9226 - 9230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Towers, M. Bock, S. Martin, Y. Takeuchi, J. P. Stoye, and O. Danos A conserved mechanism of retrovirus restriction in mammals PNAS, October 24, 2000; 97(22): 12295 - 12299. [Abstract] [Full Text] [PDF]
|
|
