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Vol. 95, Issue 16, 9078-9081, August 4, 1998
Department of Molecular Biology, Cell Biology, and Biochemistry,
Brown University, Providence, RI 02912
Contributed by George Klein, June 15, 1998
Finite replicative lifespan, or senescence, of mammalian
cells in culture is a phenomenon that has generated much curiosity since its description. The obvious significance of senescence to
organismal aging and the development of cancer has engendered a
long-lasting and lively debate about its mechanisms. Recent discoveries
concerning the phenotypes of telomerase knockout mice, the consequences
of telomerase reexpression in somatic cells, and genes that regulate
senescence have provided striking molecular insights but also have
uncovered important new questions. The objective of this review is to
reconcile old observations with new molecular details and to focus
attention on the key remaining puzzles.
Copyright © 1998 by The National Academy of Sciences 0027-8424/98/959078-4$2.00/0
Review
Can ends justify the means?: Telomeres and the mechanisms of
replicative senescence and immortalization in mammalian cells
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