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Vol. 96, Issue 16, 9379-9384, August 3, 1999

Neurobiology
 Distributed representation of objects in the human ventral visual pathway

(face perception / functional MRI / object recognition)

Alumit Ishai*, Leslie G. Ungerleider, Alex Martin, Jennifer L. Schouten, and James V. Haxby

Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1366

Communicated by Larry R. Squire, University of California, San Diego, CA, June 7, 1999 (received for review March 23, 1999)

Brain imaging and electrophysiological recording studies in humans have reported discrete cortical regions in posterior ventral temporal cortex that respond preferentially to faces, buildings, and letters. These findings suggest a category-specific anatomically segregated modular organization of the object vision pathway. Here we present data from a functional MRI study in which we found three distinct regions of ventral temporal cortex that responded preferentially to faces and two categories of other objects, namely houses and chairs, and had a highly consistent topological arrangement. Although the data could be interpreted as evidence for separate modules, we found that each category also evoked significant responses in the regions that responded maximally to other stimuli. Moreover, each category was associated with its own differential pattern of response across ventral temporal cortex. These results indicate that the representation of an object is not restricted to a region that responds maximally to that object, but rather is distributed across a broader expanse of cortex. We propose that the functional architecture of the ventral visual pathway is not a mosaic of category-specific modules but instead is a continuous representation of information about object form that has a highly consistent and orderly topological arrangement.

*   To whom reprint requests should be addressed at: National Institute of Mental Health, Building 10, Room 4C104, MSC-1366, National Institutes of Health Bethesda, MD 20892-1366. E-mail: alumit{at}ln.nimh.nih.gov.

Copyright © 1999 by The National Academy of Sciences  0027-8424/99/969379-6$2.00/0
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