PNAS Peer Review Sign up for PNAS Online eTocs
Link: Info for AuthorsLink: Editorial BoardLink: AboutLink: SubscribeLink: AdvertiseLink: ContactLink: Sitemap Link: PNAS Home
Proceedings of the National Academy of Sciences
Link: Current Issue "" Link: Archives "" Link: Online Submission ""  Link: Advanced Search

Published online on July 4, 2000, 10.1073/pnas.140029597
PNAS | July 18, 2000 | vol. 97 | no. 15 | 8364-8368


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via ISI Web of Science (65)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Papaseit, C.
Right arrow Articles by Tabony, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Papaseit, C.
Right arrow Articles by Tabony, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg  
What's this?

 Previous Article  | Table of Contents |  Next Article 

Chemistry / Cell Biology
 Microtubule self-organization is gravity-dependent

Cyril Papaseit, Nathalie Pochon, and James Tabony*

Laboratoire Résonance Magnétique en Biologie Métabolique, Département de Biologie Moléculaire et Structurale, Direction des Sciences du Vivant, Commissariat à l'Energie Atomique Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France

Edited by J. Richard McIntosh, University of Colorado, Boulder, CO, and approved May 5, 2000 (received for review January 24, 2000)

Although weightlessness is known to affect living cells, the manner by which this occurs is unknown. Some reaction-diffusion processes have been theoretically predicted as being gravity-dependent. Microtubules, a major constituent of the cellular cytoskeleton, self-organize in vitro by way of reaction-diffusion processes. To investigate how self-organization depends on gravity, microtubules were assembled under low gravity conditions produced during space flight. Contrary to the samples formed on an in-flight 1 × g centrifuge, the samples prepared in microgravity showed almost no self-organization and were locally disordered.

* To whom reprint requests should be addressed. E-mail: jtabony{at}cea.fr.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg    What's this?


This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Liu, Y. Guo, J. M. Valles Jr., and J. X. Tang
Microtubule bundling and nested buckling drive stripe formation in polymerizing tubulin solutions
PNAS, July 11, 2006; 103(28): 10654 - 10659.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Simons, E. M. Gardner, and P. I. Lelkes
Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time-dependent manner
J Appl Physiol, April 1, 2006; 100(4): 1287 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
N. D. Searby, C. R. Steele, and R. K. Globus
Influence of increased mechanical loading by hypergravity on the microtubule cytoskeleton and prostaglandin E2 release in primary osteoblasts
Am J Physiol Cell Physiol, July 1, 2005; 289(1): C148 - C158.
[Abstract] [Full Text] [PDF]

Home page
 ANN BOT (LOND)Home page
F. BALUSKA, D. VOLKMANN, and P. W. BARLOW
Eukaryotic Cells and their Cell Bodies: Cell Theory Revised
Ann. Bot., July 1, 2004; 94(1): 9 - 32.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Kossmehl, M. Shakibaei, A. Cogoli, M. Infanger, F. Curcio, J. Schonberger, C. Eilles, J. Bauer, H. Pickenhahn, G. Schulze-Tanzil, et al.
Weightlessness Induced Apoptosis in Normal Thyroid Cells and Papillary Thyroid Carcinoma Cells via Extrinsic and Intrinsic Pathways
Endocrinology, September 1, 2003; 144(9): 4172 - 4179.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Maccarrone, N. Battista, M. Meloni, M. Bari, G. Galleri, P. Pippia, A. Cogoli, and A. Finazzi-Agro
Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release
J. Leukoc. Biol., April 1, 2003; 73(4): 472 - 481.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
A.-L. Paul, C. J. Daugherty, E. A. Bihn, D. K. Chapman, K. L.L. Norwood, and R. J. Ferl
Transgene Expression Patterns Indicate That Spaceflight Affects Stress Signal Perception and Transduction in Arabidopsis
Plant Physiology, June 1, 2001; 126(2): 613 - 621.
[Abstract] [Full Text] [PDF]