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Published online on June 4, 2002, 10.1073/pnas.122218499
PNAS | June 11, 2002 | vol. 99 | no. 12 | 7917-7921


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Biochemistry
 The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways

Jong-Il Kim and Michael M. Cox*

Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706-1544

Communicated by I. Robert Lehman, Stanford University School of Medicine, Stanford, CA, April 10, 2002 (received for review December 20, 2001)

The RecA protein of Escherichia coli, and all filament-forming homologues identified to date, promote DNA strand exchange by a common, ordered pathway. A filament is first formed on single-stranded DNA, followed by uptake of the duplex substrate. These proteins are thereby targeted to single-strand gaps and tails where recombinational DNA repair is required. The observed course of DNA strand exchange promoted by the RecA protein from the extremely radioresistant bacterium Deinococcus radiodurans is the exact inverse of this established pathway. This reaction lies at the heart of a remarkably efficient system for the repair of DNA damage.

* To whom reprint requests should be addressed. E-mail: cox{at}biochem.wisc.edu.

www.pnas.org/cgi/doi/10.1073/pnas.122218499
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