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* Department of Neurosurgery, Children's Hospital, 300 Longwood
Avenue, Boston, MA 02115; Edited by Richard M. Held, Massachusetts Institute of Technology,
Cambridge, MA, and approved May 2, 2002 (received for review February
7, 2002)
Cerebral infarct (stroke) often causes devastating and irreversible
losses of function, in part because of the brain's limited capacity
for anatomical reorganization. The purine nucleoside inosine has
previously been shown to induce neurons to express a set of
growth-associated proteins and to extend axons in culture and in
vivo. We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain
to extend new projections to denervated areas of the midbrain and
spinal cord. This growth was paralleled by improved performance on
several behavioral measures.
Neurobiology
Inosine induces axonal rewiring and improves behavioral outcome
after stroke
,
,,,
Harvard Medical School, Boston,
MA 02115; § Department of Psychology and Neuroscience,
University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada
11K 3M4; and ¶ Boston Life Sciences, Incorporated, 137 Newbury Street, Boston, MA 02116
P.C. and D.E.G. contributed equally to this work.
To whom reprint requests should be addressed.
E-mail: larry.benowitz{at}tch.harvard.edu.
www.pnas.org/cgi/doi/10.1073/pnas.132076299
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