Guest-induced organization of an optimal receptor from a dynamic receptor library: Spectroscopic screening
- *Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusaku, Nagoya 464-8603, Japan; †Chemical Analysis Center, Chiba University, Yayoicho, Inageku, Chiba 263-8522, Japan; and ‡Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Chikusa-ku, Nagoya 464-8603, Japan
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Edited by Jack Halpern, University of Chicago, Chicago, IL, and approved January 14, 2002 (received for review December 3, 2001)
Abstract
Complexation of a cis-protected palladium ion and a family of exo-bidentate and -tridentate ligands results in the formation of an equilibrium mixture of numerous metal-linked receptors that are referred to as a dynamic receptor library. We found that a guest induced the selective formation of the optimal receptor of its own. Screening of the library by using difference NMR facilitates the search for new receptors because in difference NMR only receptors interacting with the guest can be observed. An unpredictable heterotopic receptor was discovered by this screening method. Interestingly, the new receptor thus found was assembled quantitatively only in the presence of its optimal guest.
Footnotes
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↵ § To whom reprint requests should be addressed. E-mail: mfujita{at}apchem.nagoya-u.ac.jp.
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This paper was submitted directly (Track II) to the PNAS office.
- Abbreviation:
- CSI,
- coldspray ionization
- Copyright © 2002, The National Academy of Sciences
