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Montreal Neurological Institute, McGill University, 3801 University
Street, Montreal, QC, Canada H3A 2B4
Communicated by Brenda Milner, McGill University, Montreal, QC,
Canada, February 15, 2002 (received for review October 28, 2001)
There is considerable uncertainty about the precise functional
contribution of the different parts of the prefrontal cortex to
mnemonic processing. Changes in regional cerebral blood flow were measured with positron emission tomography in normal human subjects exposed to abstract visual designs under various conditions. It was demonstrated that the processing of stimuli that deviate from
expectations involves selectively the orbitofrontal cortex, namely the
part of the frontal cortex that is preferentially linked with the
limbic system. By contrast, when the subject is making an explicit
decision on the contents of memory (e.g., judgments of relative
stimulus familiarity), the mid-ventrolateral prefrontal cortex is
involved. The mid-dorsolateral prefrontal cortex is engaged when
monitoring of information within working memory is required.
Neurobiology
Differential activation of the human orbital,
mid-ventrolateral, and mid-dorsolateral prefrontal cortex
during the processing of visual stimuli
*
To whom reprint requests should be addressed. E-mail:
petrides{at}ego.psych.mcgill.ca.
www.pnas.org/cgi/doi/10.1073/pnas.072092299
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