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PNAS | February 19, 2002 | vol. 99 | Suppl. 1 | 2479-2480
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Proteins: Paradigms of complexity

Hans Frauenfelder *

Center for Nonlinear Studies, MS B258, Los Alamos National Laboratory, Los Alamos, NM 87545

Proteins are the working machines of living systems. Directed by the DNA, of the order of a few hundred building blocks, selected from 20 different amino acids, are covalently linked into a linear polypeptide chain. In the proper environment, the chain folds into the working protein, often a globule of linear dimensions of a few nanometers. The biologist considers proteins units from which living systems are built. Many physical scientists look at them as systems in which the laws of complexity can be studied better than anywhere else. Some of the results of such studies will be sketched.

* E-mail: frauenfelder{at}lanl.gov.

This paper results from the Arthur M. Sackler Colloquium of the National Academy of Sciences, "Self-Organized Complexity in the Physical, Biological, and Social Sciences," held March 23–24, 2001, at the Arnold and Mabel Beckman Center of the National Academies of Science and Engineering in Irvine, CA.


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