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Published online on April 16, 2008, 10.1073/pnas.0801762105
PNAS | April 22, 2008 | vol. 105 | no. 16 | E17


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LETTERS
Lithium may slow progression of amyotrophic lateral sclerosis, but further study is needed

Richard S. Bedlack*,{dagger}, Nicholas Maragakis{ddagger}, and Terry Heiman-Patterson§

*Duke University ALS Clinic, 932 Morreene Road, Durham, NC 27705; {ddagger}The ALS Center at Johns Hopkins, 600 North Wolfe Street Baltimore, MD 21287; and §MDA/ALS Center of Hope, Drexel University College of Medicine, P.O. Box 40777, Philadelphia, PA 19107

To the Editor: In the February 12, 2008 edition of PNAS, Fornai et al. (1) suggest that lithium slows human ALS progression. We have several questions about their study.

Was this trial registered before enrollment, as required by the International Committee of Medical Journal Editors (2)? If not, why? . . . [Full Text of this Article]

{dagger}To whom correspondence should be addressed. E-mail: bedla001@mc.duke.edu


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This article has been cited by other articles in HighWire Press-hosted journals:


Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Fornai, G. Siciliano, M. L. Manca, L. Murri, A. Paparelli, and S. Ruggieri
Reply to Bedlack et al.: A small pilot study calls for large clinical trials to evaluate the effects of lithium before prescribing the drug for amyotrophic lateral sclerosis
PNAS, April 22, 2008; 105(16): E18 - E18.
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