The narrow escape problem for diffusion in cellular microdomains
- †Department of Mathematics, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel;
- ‡Department of Mathematics, Program in Applied Mathematics, Yale University, 10 Hillhouse Avenue, PO Box 208283, New Haven, CT 05620-8283;
- §Department of Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel; and
- ¶Départment de Mathématiques et de Biologie, Ecole Normale Supérieure, 46 Rue d'Ulm, 75005 Paris, France
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Communicated by Robert H. Austin, Princeton University, Princeton, NJ, July 13, 2007 (received for review January 15, 2007)
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Fig. 1.The escape of a Brownian trajectory through a small window.
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Fig. 2.Homogenization of the PSD. (Right) Scattered free, bound, and scaffolding molecules and other obstacles and fences in the PSD. (Left) A course-grained model with concentrated free (green), bound (orange), and scaffolding and other molecules (brown) (see text). [Reproduced with permission from ref. 29 (Copyright 2006, Biophysical Society).]
Footnotes
- ‖To whom correspondence should be addressed. E-mail: holcman{at}biologie.ens.fr
- © 2007 by The National Academy of Sciences of the USA
